[1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or

Details [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or [1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or

1974-07-31

1977-02-01

Killos, Paul J.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

260308D, 2603322A, 2603323R, 260465F, 260470, 2605011, 260516, 260520C, 260559B, 260623R, C07C 6976

Patent

active

040061809

ABSTRACT:
[1,3-Dihydroxy-2-substituted and 2,2-disubstituted-indanyloxy(or thio)]alkanoic acids and their salts, esters and amides are disclosed. The products display a dual pharmaceutical utility in that they exhibit diuretic, saluretic and uricosuric activity. The acid products are prepared by treating a 1,3-dioxo-2-substituted or 2,2-disubstituted-indanyloxy(or thio)alkanoic acid with a reducing agent.

REFERENCES:
patent: 3369025 (1968-02-01), Bolhofer
patent: 3668241 (1972-06-01), Cragoe et al.
patent: 3704314 (1972-11-01), Cragoe et al.
patent: 3776944 (1973-12-01), Brown et al.
patent: 3906032 (1975-09-01), Hauck
Topless et al, J. Pharm. Sci. 57 (5) p. 737 (1968).

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