1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, subst

Details 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, subst 1,3-Dihydro-3-hydroxy-5-phenyl-2H-1,4-benzodiazepin-2-one, subst

1972-02-04

1977-12-27

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

424244, 424250, 424256, 424267, 424274, 42424854, 424251, 424273R, 424273P, 2602433, C07D24324, C07D40312

Patent

active

040654516

ABSTRACT:
This invention is directed to novel central nervous system depressants of Formula I ##STR1## wherein R.sup.1 is selected from the group consisting of (lower)alkyl and ar(lower)alkyl; R.sup.2 is selected from the group consisting of di(lower)alkylamino(lower)alkyl and diaryl(lower)alkylamino(lower)alkyl; R.sup.1 and R.sup.2 may be concatenated to form a radical selected from the group consisting of ##STR2## wherein R.sup.4 is selected from the group consisting of (lower)alkyl, aryl, hydroxy(lower)alkyl, ar(lower)alkyl and (lower)alkoxy(lower)alkyl; R.sup.5 is selected from the group consisting of (lower)-alkylamino and piperidino; n is an integer from 3 to 5; m is an integer from 1-2; r is an integer from 2 to 3; s is an integer from 0 to 6; t is an integer from 0-6; with the proviso that the sum of s and t is 3 to 6; R.sup.3 is selected from the group consisting of hydrogen, (lower)alkyl, ar(lower)alkyl and (lower)alkoxy(lower)alkyl; X is selected from the group consisting of halogen, cyano, trifluoromethyl, nitro and (lower)alkylthio; Y is selected from the group consisting of hydrogen, halogen, trifluoromethyl, nitro and (lower)alkylthio; and the pharmaceutically acceptable salts thereof, in addition to the method of their preparation and administration and administrable compositions containing the active compounds.

REFERENCES:
patent: 3296249 (1967-01-01), Bell
patent: 3391138 (1968-07-01), Archer et al.
Bell et al., "J. Med. Chem.", vol. 11, pp. 457-461, (1968).

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