1,3-Dihydro-3-(2-hydroxy-, 2-bromo- or 2-chloroethyl)-2H-isoindo

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...

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260325PH, A61K 3140, C07D20946

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active

042449669

ABSTRACT:
Derivatives of 1,3-dihydro-3-(2-hydroxyethyl) -2H-isoindol-1-one are disclosed. The derivatives are useful for treating ulcers in a mammal and for preventing or decreasing the secretion or availability of excessive amounts of gastric or hydrochloric acid in a mammal suffering from hyperchlorhydria and/or associated conditions.

REFERENCES:
patent: 3892771 (1975-07-01), Eberle
H. J. Roth et al., Arch. Pharm., 309, 58 (1976).
Derwent Publications Ltd., Farmdoc 21903V for Japanese Patent J49014459.
Chem. Abst. 78:58179S (1973) for Tetra. Letters, 4517 (1972).
Chem. Abst. 55:15485c (1961) for Gazz. chim. ital., 90559 (1960).
E. Breuer et al., Tetrahedron, 31, 499 (1975).
F. M. Rowe et al., J. Chem. Soc. 1098 (1936).
Chem. Abstracts 80:108372p (1974), Abstract of Japanese Kokai, 74 14,459.
Chem. Abstracts 85:46384m (1976).
H. Roth et al., Arch. Pharm. 309 pp. 58 et seq. (1976).

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