1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones

Details 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones

1989-08-02

1991-04-09

Lee, Mary C.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514278, 514333, 546 15, 546 17, 546256, 546273, A61K 3144, C07D21374

Patent

active

050065378

ABSTRACT:
This invention relates to 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones of the formula ##STR1## where R.sub.1,R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; or R.sub.2 and R.sub.3 together form a cycloalkane ring of 4 to 6 carbons or a spiro-fused aryl or heteroaryl cycloalkane; X and Y are independently hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; m and n are independently integers of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and, where applicable the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics, anticonvulsants, for enhancing memory and for the treatment of Alzheimer's disease.

REFERENCES:
Avedeyev, et al., 6-Substituted-1-Heterocyclic Arylamino-3-Arylhydroxyindoles, Khim. Geterotsikl (4) 524-7 (1983).

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