1,3-dihydro-1-amino-2H-indol-2-ones

Details 1,3-dihydro-1-amino-2H-indol-2-ones 1,3-dihydro-1-amino-2H-indol-2-ones

1995-04-28

1997-11-11

Fan, Jane

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D20902

Patent

active

056866267

ABSTRACT:
This invention relates to 1,3-dihydro-1-(pyridinylamino)-2H-indol-2-ones of the formula ##STR1## where R.sub.1, R.sub.2 and R.sub.3 are independently hydrogen, loweralkyl, aryl, arylloweralkyl or heteroarylloweralkyl selected from the group consisting of pyridinylmethyl, pyridinylethyl, thienylmethyl, thienylethyl; or R.sub.2 and R.sub.3 together form a cycloalkane ring of 4 to 6 carbons or a spiro-fused aryl cycloalkane or heterocycloalkyl selected from the group consisting of piperidine and tetrahydropyran; X and Y are independently hydrogen, halogen, hydroxy, loweralkyl, loweralkoxy, nitro, amino or trifluoromethyl; m and n are independently integers of 1 to 3, the pharmaceutically acceptable acid addition salts thereof and, where applicable the optical, geometrical and stereoisomers and racemic mixtures thereof. The compounds of this invention display utility as analgesics, anticonvulsants, for enhancing memory and for the treatment of Alzheimer's disease.

REFERENCES:
patent: 3975531 (1976-08-01), Welstead, Jr. et al.
patent: 4182774 (1980-01-01), Welstead, Jr. et al.
patent: 4260767 (1981-04-01), Dusza
patent: 5064852 (1991-11-01), Howard, Jr. et al.
CA 112:178841, Zey et al. 1990.
V.B. Avdeyev, et al., Khimiya Geterotsiklicheskikh Soedinenii, 524 (1983) published in the Soviet Union and entitled "6-Substituted-1-Heterocyclic Arylamino-3-Arylhydroxyindoles" and English translation thereof.
H.E. Baumgarten, et al., 82, 3977 (1960) published in the United States of America and entitled "Cinnolines. VI. The Structure of Neber's Lactam. A New Synthesis of 3-Cinnolinol:".
G. Winters, et al., Chemical Abstracts, 102, 78764w (1985) published in the United States of America and entitled "Synthesis and pregnancy terminating

Affiliated with

Also associated with

Rating

1,3-dihydro-1-amino-2H-indol-2-ones does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,3-dihydro-1-amino-2H-indol-2-ones, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3-dihydro-1-amino-2H-indol-2-ones will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1230524