1,3-diheterocyclic metalloprotease inhibitors

Details 1,3-diheterocyclic metalloprotease inhibitors 1,3-diheterocyclic metalloprotease inhibitors

1997-08-26

2000-11-21

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514258, 514259, 514269, 544230, 544231, 544243, 544244, 544253, 544278, 544279, 544280, 544283, 544284, 544287, 544298, 544319, 544326, 544327, 544328, 544329, 544333, 544335, A61K 31505, C07F 902, C07D23900, C07D48700

Patent

active

061503703

ABSTRACT:
Disclosed are compounds which are inhibitors of metalloproteases having the following structure: ##STR1## where Ar, W, X, Y, Z, R.sub.1 and R.sub.2 have the meanings described in the specification and optical isomers, diastereomers, and enantiomers thereof or a pharmaceutically-acceptable salt, or biohydrolyzable amides, esters, or imides thereof. Also disclosed are pharmaceutical compositions and methods of treating diseases, disorders and conditions characterized by unwanted metalloprotease activity using these compounds or pharmaceutical compositions.

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