Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1997-07-22
1999-11-09
Richter, Johann
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
5142292, 514360, 514363, 514364, 514396, 514397, 514398, 514399, 514400, 548122, 548128, 548129, 548130, 548131, 548132, 548133, 5483171, 5483201, 544 68, 560 15, 560 38, 560 41, 562426, 562433, 562443, A61K 3141, C07D28508, C07D285125, C07D41706
Patent
active
059815566
ABSTRACT:
1,3-diazolino and 1,3-diazolidino heterocycle derivatives useful as nitric oxide synthase inhibitors.
REFERENCES:
patent: 2049582 (1936-08-01), Ziegler
patent: 3109848 (1963-11-01), Bortnick et al.
patent: 3121093 (1964-02-01), Bortnick et al.
patent: 3132151 (1964-05-01), Bortnick et al.
patent: 3501487 (1970-03-01), Poos
patent: 3563994 (1971-02-01), Wollweber et al.
patent: 3694432 (1972-09-01), Hershenson
patent: 3725435 (1973-04-01), Poos
patent: 3816457 (1974-06-01), Grisar et al.
patent: 4046909 (1977-09-01), Rasmussen et al.
patent: 4061746 (1977-12-01), Blohm et al.
patent: 4126613 (1978-11-01), Grisar et al.
patent: 4126621 (1978-11-01), Grisar et al.
patent: 4153235 (1979-05-01), Grisar et al.
patent: 4443468 (1984-04-01), Maillard et al.
patent: 4523020 (1985-06-01), Moormann et al.
patent: 4525476 (1985-06-01), Butler et al.
patent: 4533739 (1985-08-01), Pitzele et al.
patent: 4556674 (1985-12-01), Maillard et al.
patent: 4579951 (1986-04-01), Pitzele et al.
patent: 4699918 (1987-10-01), Maillard et al.
patent: 4855444 (1989-08-01), Wambach
patent: 4962204 (1990-10-01), Wambach
patent: 5015633 (1991-05-01), Sudilovsky
patent: 5028627 (1991-07-01), Kilbourn et al.
patent: 5051444 (1991-09-01), Tamoto et al.
patent: 5059712 (1991-10-01), Griffith
patent: 5081148 (1992-01-01), Braquet et al.
patent: 5132453 (1992-07-01), Griffith
patent: 5196439 (1993-03-01), Sugimoto et al.
patent: 5216025 (1993-06-01), Gross et al.
patent: 5246971 (1993-09-01), Williamson et al.
patent: 5266594 (1993-11-01), Dawson et al.
patent: 5273875 (1993-12-01), Griffith
patent: 5621004 (1997-04-01), Dunn et al.
patent: 5629322 (1997-05-01), Guthikonda et al.
Moro et al., "cGMP mediates the vascular and platelet actions of nitric oxide: Confirmation using an inhibitor of the soluble guanylyl cyclase," Proc. Natl. Acad. Sci., vol. 93, No. 4, pp. 1480-1485, Feb. 20, 1996.
Perrin et al., "Absence of Stereoelectronic Control in Hydrolysis of Cyclic Amidines", J. Am. Chem. Soc., vol. 108, No. 19, pp. 5997-6003, 1986.
Huber et al., "Saturated Heterocycles, Part 88. Synthesis of a New Ring System: Dipyrido-[1.2-a:4,3-d]pyrimidin-11-one Derivatives", J. Chem. Soc. Perkin Trans. 1, pp. 909-912, 1987.
Kokosi et al., "Nitrogen Bridgehead Compounds. Part 19(1). Synthesis of Polymethylenepyrimidin-4-ones ", J. Heterocyclic Chem., vol. 19, pp. 909-912, 1982.
Brown et al., Hydropyrimidines, Part II, pp. 4041-4045, 1962.
Adcock et al., 2-Amino-2-imidazolines 2-Amino-2-oxazolines, Part II, pp. 474-479, 1965.
Stefanye et al., "Cyclic Guanidines from Nitrimino Compounds", J. Am. Chem. Soc., vol. 77, No. 3, pp. 761-762, 1955.
Klayman et al., "2-Amino-2-thiazoline. VII. Unequivocal Structure Assignment of the Products of the Reaction of 2-Amino-2-thiazoline and Its Analogs with Carbethoxy Isothiocyanate", J. Org. Chem., vol. 39, No. 13, pp. 1819-1823, 1974.
Moriconi et al., "Synthesis and Reactions of Cyclic Amidines", J. Org. Chem., vol. 33, No. 5, pp. 2109-2111, 1968.
Wagenaar et al., "Methodology for the Preparation of N-Guanidino-Modified Arginines and Related Derivatives", J. Org. Chem., vol. 58, No. 1, pp. 4331-4338, 1993.
Gutteridge, "Acylation of 2-Amino-5,5-dimethyl-.increment.-pyrroline 1-Oxide", J. Chem. Soc., (C), pp. 3121-3125, 1971.
Langlois et al., "Derivatives of Imidazole, 1,3,4-triazole and tetrazole", J. Heterocycl. Chem., vol. 19, No. 1, pp. 193-200, 1982 (English Summary, p. 200).
Langlois et al., "Synthesis and Antidepressant Properties of 2-Amino-4-phenyl-1-pyrroline Derivatives", Eur. J. Med. Chem., vol. 13, No. 2, pp. 161-169, 1978 (English Summary, p. 169).
Klotzer et al. "Acylderivatives of 2-Amino-1-pyrrolines", Monatshefte fur Chemie, vol. 102, No. 2, pp. 627-634, 1971 (English Summary, p. 627).
Klotzer et al. "Synthesis of Substituted 2-Amino-1-pyrrolines, I." Monatshefte fur Chemie, vol. 101, No. 5, pp. 1263-1270, 1970 (English Summary, p. 1263).
Nakane et al., "Novel Potent and Selective Inhibitors of Inducible Nitric Oxide Synthase", Molecular Pharmacology, vol. 47, pp. 831-834, 1995.
Dunbar et al., "Design, Synthesis, and Neurochemical Evaluation of 2-Amino-5-(alkoxycarbonyl)-3,4,5,6-tetrahydopyridines and 2-Amino-5-(alkoxycarbonyl)-1,4,5,6-tetrahydropyrimidines as M.sub.1 Muscarinic Receptor Agonists", J. Med. Chem., vol. 37, No. 17, pp. 2774-2782, 1994.
Klotzer et al. "Synthesis of Substituted 2-Aminopyrrolines, II." Monatshefte fur Chemie, vol. 101, No. 6, pp. 1841-1850, 1970 (English Summary, p. 1841).
Berge et al., "Pharmaceutical Salts", J. Pharm. Sci., vol. 66, No. 1, pp. 1-19, 1977.
Moncada et al., "Nitric Oxide: Physiology, Pathophysiology, and Pharmacology", Pharmacological Reviews, Vo. 43, No. 2, pp. 109-142, 1991.
Moncada et al, "Biosynthesis of Nitric Oxide from L-Arginine", Biochemical Pharm., vol. 38, No. 11, pp. 1709-1715, 1989.
Mazurek et al., "Theoretical Studies of Tautomerism of Clonidine Vacuum and in Water Medium", Theochem, 82(1-2), 23-8, 1991 (Abstract Only).
Bertolini et al., "Nitric Oxide Synthase Inhibitors: Recent Advances", Cardiovascular & Renal Patent Update, Ashley Publications Ltd., pp. 1339-1345, 1994.
Culvenor, C.C.J. et al, Aust. J. Chem., 24 (1971) 371-375.
Caujolle, R. et al, Eur. J. Med. Chem. Chim. Ther., 28(1) (1993) 29-35.
Kato et al, Chem. Pharm. Bull., 20 (1972) 901.
Anderson, Wayne K. et al, Synth. Commun., 19(13-14) (1989) 2237-2242.
Olomucki et al, Biochim. Biophys. Acta, 263 (1972) 213-216.
Otake, N. et al, Tetrahedron Lett., 19 (1965) 1411-1419.
Patent: Kerin Seiyaku Kabushiki Kaisya, JP, A, 17189, 1968; Referati vnyi Zhurnal. Khimiya., 1 (1970) N469P.
Umezawa et al, J. Antibiot., 26 (1973) 625, 637.
Bycroft et al., J. Antibiot., 22 (1969) 133-134.
Bycroft et al., J. Chem. Soc.(C), (1971) 3040-3046.
Marconi et al, J. Antibiot., 23 (1970) 120-124.
Kretow et al, J. Gen. Chem. USSR, 32 (1962) 464.
Dorn et al, Chem. Ber., 103 (1970) 2505-2511.
Andrewes et al, Proc. R. Soc. London B, 133 (1946) 20, 53 (Beilstein Registry ID Only).
Schubert, H. W. et al, Arch. Pharm. Ber. Dtsch. Pharm. Ges., 301(10) (1968) 750-762.
Rodricks et al, J. Org. Chem., 36 (1971) 46-48.
Stefanye et al, J. Amer. Chem. Soc., 77 (1955) 761-762.
Goodman et al, J. Org. Chem., 23 (1958) 1251-1255, 1954-1956.
Bergmanis Arija A.
Gapud Rolando E.
Hagen Timothy J.
Hallinan E. Ann
Hansen, Jr. Donald W.
G.D. Searle & Co.
Oswecki Jane C.
Richter Johann
Scrivner Alan L.
LandOfFree
1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric , we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,3-diazolino and 1,3-diazolidino heterocycles as useful nitric will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1456476