1,3-diaryl cyclopentanes and derivatives thereof as PAF antagoni

Organic compounds -- part of the class 532-570 series – Organic compounds – Sulfur containing

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568 29, 568 34, C07C31714, C07C31722

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active

051324636

ABSTRACT:
Novel 1,3-Diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediated by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.

REFERENCES:
patent: 4845129 (1989-07-01), Anderson et al.
patent: 5047420 (1991-09-01), Graham
P. Ruggli et al., J.O.C., 26, 307 (1961).
Strashneuko et al., 2h Org. Khim., 3, 91 (1967).
D. H. Richards et al., J. Chem. Soc. (c) 2661 (1969).

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