1,3-diaryl cyclopentanes and derivatives thereof as PAF antagoni

Details 1,3-diaryl cyclopentanes and derivatives thereof as PAF antagoni 1,3-diaryl cyclopentanes and derivatives thereof as PAF antagoni

1989-08-21

1991-09-10

Raymond, Richard L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

N-c doai

514487, 514490, 514520, 514522, 514524, 514525, 514530, 514562, 514563, 514570, 514571, 514574, 514595, 514602, 514603, 514618, 514619, 514621, 514622, 514640, 514647, 514684, 514719, 514720, 514734, 514751, 514764, 558406, 558408, 558409, 558412, 558413, 558415, 558418, 558419, 558420, 558422, 560 12, 560 13, 560 18, 560 19, 560 20, 560 21, 560 22, 560 27, 560 31, 560 32, 562426, 562429, 562430, 562432, 562435, 562441, 562442, 562454, 562455, 562457, 564 47, 564 80, 564 83, 564 85, 564 86, 564 87, 564 88,

Patent

active

050474200

ABSTRACT:
Novel 1,3-diaryl cyclopentanes of the following general formula were prepared. ##STR1## These compounds were found to have potent and specific PAF (Platelet Activating Factor) antagonistic activities and as such useful in the treatment or amelioration of various diseases or disorders mediate by the PAF, for example, hypotension, inflammation, nephritis, stroke and other cardiovascular disorders, asthma, allergic and skin diseases, peptic or stomach ulcer, shock, lung edema, psoriasis, adult respiratory distress syndrome, pain including dental pain, and aggregation of platelets.

REFERENCES:
patent: 4054604 (1977-10-01), Bernady et al.
patent: 4360531 (1982-11-01), McMillan et al.
patent: 4460600 (1984-07-01), Kaplan et al.
patent: 4845129 (1989-07-01), Anderson et al.

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