1,3-Di-amino-alkane-1,1-diphosphonic acids and salts

Details 1,3-Di-amino-alkane-1,1-diphosphonic acids and salts 1,3-Di-amino-alkane-1,1-diphosphonic acids and salts

1976-07-16

1977-12-20

Evans, Joseph E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

210 58, 252 88, 252180, 252545, 26050112, 424 54, 424204, C07F 938, C02B 506, A61K 722

Patent

active

040641643

ABSTRACT:
1,3-Di-amino-alkane-1,1-diphosphonic acids having the formula ##STR1## wherein R.sub.1 and R.sub.2 are members selected from the group consisting of hydrogen and alkyl having 1 to 3 carbon atoms, and R.sub.3 is a member selected from the group consisting of hydrogen and methyl; as well as their water-soluble salts. The 1,3-diamino-alkane-1,1-diphosphonic acids are excellent sequestering agents especially for alkaline earth metal ions. The compounds are useful in pharmaceutical preparations for treatment of disturbances of calcium or phosphate metabolism or cosmetic preparations such as toothpastes or mouth washes for the prevention of tartar and plaque depositions.

REFERENCES:
patent: 3398127 (1968-08-01), Suling et al.
patent: 3919296 (1975-11-01), Schindler et al.
patent: 3925456 (1975-12-01), Ploger et al.
patent: 3976762 (1976-08-01), Kohler et al.
patent: 4005160 (1977-01-01), Redmore et al.

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