(1,3) .beta.-glucan synthase genes and inducible inhibition of f

Details (1,3) .beta.-glucan synthase genes and inducible inhibition of f (1,3) .beta.-glucan synthase genes and inducible inhibition of f

1995-12-28

1999-06-15

Grimes, Eric

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Transferase other than ribonuclease

435 911, 435 9141, 4352523, 4353201, 435325, 536 232, C12N 121, C12N 1554, C12N 1563, C12P 2102

Patent

active

059121530

ABSTRACT:
A (1,3).beta.-glucan synthase mutant useful in the research and development of anti-fungal drugs. A key step in fungal wall assembly, hyphal growth and infection is the synthesis of (1,3).beta.-linked glucan. Because .beta.-glucan is not made by humans, (1,3).beta.-glucan synthase is an attractive target for development of new antifungal antibiotics. A (1,3).beta.-glucan synthase gene has been cloned and the cDNA sequence and polypeptide amino acid sequence of the gene has been established.

REFERENCES:
patent: 4873196 (1989-10-01), Selitrennikoff
patent: 5194600 (1993-03-01), Bussey et al.
patent: 5484724 (1996-01-01), El-Sherbeini et al.
Enderlin et al., Proc. Natl. Acad. Sci. USA 91:9500-9504, 1994
Taft et al., J. Antibiotics 41:697-701, 1988.
Taft et al., J. Enzyme Inhib. 5:41-49, 1991.

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