1,3-Benzoxazine trichloromethyl derivatives, compositions and us

Details 1,3-Benzoxazine trichloromethyl derivatives, compositions and us 1,3-Benzoxazine trichloromethyl derivatives, compositions and us

1979-08-28

1981-05-19

Jiles, Henry R.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

42424854, 42424855, 544 92, A61K 31535, C07D26522

Patent

active

042685109

ABSTRACT:
The invention relates to novel heterocyclic trichloromethyl derivatives, particularly 2-trichloromethyl-substituted quinazoline, benzo[d]-[1,3]-oxazine and benzo[e]-[1,3]-oxazine derivatives, for example 1,2-dihydro-2-trichloromethylquinazolin-4-one. The compounds of the invention are at least as effective as prior art trichloromethyl derivatives, which reduce the production of methane during the rumen metabolism of ruminant animals, and increase the formation of propionate at the expense of acetate, and hence improve the animals' rate of growth and their efficiency of food utilization.

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Rana, Chem. Abstracts, vol. 37 (1943), pp. 2361-2362.
Rana et al., Chem. Abstracts, vol. 34, p. 2819.
Monti, Chem. Abstracts, vol. 34, p. 7292.
Hirwe et al., Chem. Abstracts, vol. 35 (1941) pp. 5502-5503.
Horrom et al., JACS, (1950) vol. 72, pp. 721-724.
Gilman et al., J. Org. Chem., (1976) vol. 41, pp. 737-739.

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