1, 3-benzothiazinone derivatives and use thereof

Details 1, 3-benzothiazinone derivatives and use thereof 1, 3-benzothiazinone derivatives and use thereof

2008-07-15

2008-07-15

Habte, Kahsay (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C544S050000

Reexamination Certificate

active

07399759

ABSTRACT:
This invention provides a compound represented by the formula (I):wherein R1is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

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Chemical Abstracts, vol. 51, Col. 17927-17930, (1957), Conti et al.
Examination Report in EPO Application 02 762 953 dated Sep. 6, 2007.
S. Pallazzo and L.I. Giannola,Atti Accad. Sci., Lett. Arti Palermo. Parte I(1976) 34(2), 73-82.
L. Conti and G. Leandri,Boll. Sci. Fac. Chim. Ind. Bologna15:37-39 (1957).
S. Pallazzo and L.I. Giannola,Attl Accad. Sci., Lett. Arti Palermo, Parte I(1976) 34(2), 73-82 (with English translation).

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