1, 3-benzothiazinone derivatives and use thereof

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C544S050000

Reexamination Certificate

active

07399759

ABSTRACT:
This invention provides a compound represented by the formula (I):wherein R1is a hydrogen atom, a halogen atom, hydroxy, nitro, optionally halogenated alkyl, alkoxy optionally having substituents, acyl or amino optionally having substituents; R2is pyridyl, furyl, thienyl, pyrrolyl, quinolyl, pyrazinyl, pyrimidinyl, pyridazinyl, indolyl, tetrahydroquinolyl or thiazolyl, each of which may have substituents; n is 1 or 2; or a salt. And this invention provides a safe pharmaceutical comprising the compound of the formula (I), which has an excellent apoptosis inhibitory effect and MIF binding effect, for preventing and/or treating heart disease, nervous degenerative disease, cerebrovascular disease, central nervous infectious disease, traumatorathy, demyelinating disease, bone and articular disease, kidney disease, liver disease, osteomyelodysplasia, AIDS, cancer, and the like.

REFERENCES:
patent: 2003/0186971 (2003-10-01), Kimura et al.
patent: 2006/0034832 (2006-02-01), Kimura et al.
patent: 1325918 (2003-07-01), None
patent: WO 02/18356 (2002-03-01), None
Chemical abstracts, vol. 51, Col. 17927-17930.
Conti et al. Bollettino Scientifico della Facolta di Chimica Industriale di Bologna (1957), 15, 37-9 (Abstract in English, STN printout 2 pages).
XP002295355, 6001 Chemical Abstracts, Columbus, Ohio, US, (1978), p. 621, vol. 89, No. 5.
Chemical Abstracts, vol. 51, Col. 17927-17930, (1957), Conti et al.
Examination Report in EPO Application 02 762 953 dated Sep. 6, 2007.
S. Pallazzo and L.I. Giannola,Atti Accad. Sci., Lett. Arti Palermo. Parte I(1976) 34(2), 73-82.
L. Conti and G. Leandri,Boll. Sci. Fac. Chim. Ind. Bologna15:37-39 (1957).
S. Pallazzo and L.I. Giannola,Attl Accad. Sci., Lett. Arti Palermo, Parte I(1976) 34(2), 73-82 (with English translation).

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