1,3-benzodioxole and 1,2-dialkoxybenzene derivatives as ocular h

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514 95, 514452, 514464, 514466, 549 6, 549 60, 549220, 549362, 549302, 549434, 549445, 549446, 549447, A61K 3136, A61K 3138, C07D40906, C07D31754

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058146571

ABSTRACT:
Compounds of the formula ##STR1## wherein the variables are defined as in the specification, are capable of lowering introaocular pressure in the eye of a mammal.

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De Farias et al., CA 106: 4705 (1987).
Bito, L. Z., Applied Pharmacology in the Medical Treatment of Glaucomas, Drance, S.M. and Neufeld. A.H. eds., New York, Grune & Stratton, 1984 pp. 477-505.
Journal of Medicinal Chemistry 1975, vol. 18, pp. 1094-1098 by Bender et al.
Bito, L. Z., Biological Protection with Prostaglandins, Cohen, M.M., ed., Boca Raton Fla. CRC Press Inc., 1985, pp. 231-252.
M.S. Starr, Exp. Eye Res. 11, 170-177 (1971).
Barreiro et al., J. Chem Res. Symop., 7, pp. 220-221 (1985) (C.A. 104: 1943c, 1986).

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