Chemistry of carbon compounds – Miscellaneous organic carbon compounds – C-metal
Patent
1976-05-10
1977-09-27
Coughlan, Jr., Paul M.
Chemistry of carbon compounds
Miscellaneous organic carbon compounds
C-metal
C07D24308
Patent
active
040511251
ABSTRACT:
1,3-Benzodioxol derivatives, the new compounds, represented by the formula: ##STR1## AND THE PHARMACOLOGICALLY ACCEPTABLE ACID-ADDITION SALTS THEREOF ARE PROVIDED, WHEREIN R.sub.1 and R.sub.2 are lower alkyls or the both together may form a divalent alkylene, R.sub.3 is a lower alkyl, phenyl, halogen-substituted phenyl or benzhydryl group, n is an integer of 2 or 3, and X stands for carbonyl (CO) or methylene (CH.sub.2) bridge. The compounds in which X stands for the methylene exhibit durable anti-histamic activity with low toxicity, and are useful for therapeutic purposes, while the compounds in which X stands for the carbonyl bridge are easily convertible by reduction into the former compounds.
REFERENCES:
patent: 3119826 (1964-01-01), Regnier et al.
patent: 3981864 (1976-09-01), Tanaka et al.
Tanaka Satoru
Watanabe Hideaki
Coughlan, Jr. Paul M.
Eisai Co. Ltd.
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