1,3-Benzodioxin derivatives

Details 1,3-Benzodioxin derivatives 1,3-Benzodioxin derivatives

1979-04-30

1981-10-13

Love, Ethel G.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

2603403, 2603409R, 568722, A61K 31335, C07D31908

Patent

active

042948452

ABSTRACT:
Novel racemic mixtures or optically active isomers of 1,3-benzodioxins of the formula ##STR1## wherein R.sub.1 ' is selected from the group consisting of hydrogen, alkali metal, alkaline earth metal, --NH.sub.4, aluminum, non-toxic, pharmaceutically acceptable amines, alkyl of 1 to 5 carbon atoms, 2,3-dihydroxypropanyl, (2,2-dimethyl-1,3-dioxolan-4-yl)methyl and dialkylaminoalkyl with alkyls of 1 to 4 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen and alkyl of 1 to 5 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 5 carbon atoms and phenyl and R.sub.4 and R.sub.5 are individually selected from the group consisting of hydrogen and halogen, and the non-toxic, pharmaceutically acceptable acid addition salts where R.sub.1 ' is dialkylaminoalkyl, with the proviso that R.sub.2 and R.sub.3 are not hydrogen simultaneously having hypolipemic activity and their preparation.

REFERENCES:
patent: 3835159 (1974-09-01), Najer et al.
patent: 3836543 (1974-09-01), Grisar
patent: 4046762 (1977-09-01), Manghisi et al.
patent: 4056540 (1977-11-01), Buchanan et al.

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