1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as sel

Details 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as sel 1,3- and 2,3-diarylcycloalkano and cycloalkeno pyrazoles as sel

1999-10-20

2000-07-04

Ramsuer, Robert W.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5483601, A61K 31403, C07D23154, C07D23156

Patent

active

060839694

ABSTRACT:
This invention is directed to certain 1,3- and 2,3-diarylpyrazole antiinflammatory compounds of the general formulae: ##STR1## wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, halogen, (C.sub.1 -C.sub.6)alkyl, (C.sub.1 -C.sub.6)alkoxy, nitro, amino, hydroxy, trifluoro, --S(C.sub.1 -C.sub.6)alkyl, --SO(C.sub.1 -C.sub.6)alkyl and --SO.sub.2 (C.sub.1 -C.sub.6)alkyl and the fused moiety Q is a group selected from the group consisting of an optionally substituted cyclohexyl and cycloheptyl group as herein described, pharmaceutical compositions containing the compounds, processes for their production and use as COX-2 inhibitor and antiinflammatory agents.

REFERENCES:
patent: 5387602 (1995-02-01), Ferro
patent: 5783597 (1998-07-01), Beers et al.
J.Med. Chem. 1997 1,2-Diarylpyrroles Aspotent and Selective Inhibitors of Cyclooxygenase-2 Ish K. Khanna et al. pp. 1619 & 1620.
Exp Opin. Invest Drugs (1997) 6(7); pp. 805-809, Nigel d. Staite Future Therapies For Rheumatoid Arthritis.
J.Med. Chem1997, 40, 1347, Thomas D. Penning et al. Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:Indentification of 4-[5-(4-Methylphenyl)-3-(Trifluoromethyl)-1H-Pyrazol-1-yl]Benzenesulfonami de(SC-58635,Celecoxib).
J.Med Chem. 1997, 40, 1634-1635, Ish K. Khanna et al., 1,2-Diarylimidazoles as Potent, Cyclooxygenase-2 Selective, and Orally Active Antiinflammatory Agents.

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