1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the tre

Details 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the tre 1,3,6-trihydro-6-aza-3-oxapentalen-2-one derivatives for the tre

1999-02-26

2000-12-12

McKane, Joseph

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514421, 548453, A61K 31407, C07D48702

Patent

active

061600032

ABSTRACT:
1,3,6-Trihydro-6-Aza-3-Oxapentalen-2-One Derivatives of Formula I are useful for inducing or promoting apoptosis and for arresting uncontrolled neoplastic cell proliferation, and are specifically useful in the arresting and treatment of neoplasia: ##STR1## Wherein R.sub.1 and R.sub.2 are independently selected from the group consisting of hydrogen, lower alkyl, and benzyl,

REFERENCES:
patent: 4414225 (1983-11-01), Sauter et al.

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