1,3,5-trisubstituted-5-phenyl and 5-pyridyl...

Details 1,3,5-trisubstituted-5-phenyl and 5-pyridyl... 1,3,5-trisubstituted-5-phenyl and 5-pyridyl...

2007-09-11

2007-09-11

Berch, Mark L. (Department: 1624)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

C514S262100, C514S228500, C514S234200, C540S553000, C544S262000, C544S061000, C544S118000, C544S231000

Reexamination Certificate

active

10866198

ABSTRACT:
Pyrazolopyrimidinone derivatives expressed by the following general formula (IA) or (IB):where the symbols are as disclosed in the specification, are provided as desired compounds. These compounds selectively inhibiting PDE7, thereby increasing the intracellular cAMP level and inhibiting the activation of T cells. Thus, these compounds are useful for prevention and treatment of various allergic diseases and inflammatory or immunological diseases.

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Martinez, Ana, et al., “Benzyl Derivatives of 2,1,3-Benzo- and Benzothieno[3,2-a]thiadiazine 2,2-Dioxides: First Phosphodiesterase 7 Inhibitors,”J. Med. Chem., 43:683-689 (2000).
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Li, Linson, et al., “CD3- and CD28-Dependent Induction of PDE7 Requirement for T Cell Activation,”Science, 283:848-851 (1999).

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