1,3,5-tribsubstituted indazole derivatives, processes for prepar

Details 1,3,5-tribsubstituted indazole derivatives, processes for prepar 1,3,5-tribsubstituted indazole derivatives, processes for prepar

1997-03-20

1998-07-07

Ambrose, Michael G.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

514259, 514274, 514314, 514338, 514378, 514394, 514418, 544116, 544284, 544310, 546176, 5462757, 548 247, 5483051, 5483615, A61K 31535, A61K 31505, A61K 3147, A61K 3144, A61K 3142, A61K 31415, C07D41312, C07D41306, C07D40912, C07D40906, C07D40312, C07D40306, C07D40112, C07D40106, C07D23156

Patent

active

057769320

ABSTRACT:
1,3,5-trisubstituted indazole derivatives of the formula ##STR1## wherein R1 is H, (b) a C.sub.1-6 straight or branched, substituted or unsubstituted alkyl residue, (c) a C.sub.3-7 cycloalkyl residue, (d) an unsustituted or substituted phenyl, naphthyl, anthranyl, or fluorenyl residue, (e) a quinolin-2-ylmethoxy, or pyridin-2-ylmethoxy residue; X is O, or a --NH, --NH--(C.dbd.O)--NH--, --NH--(C.dbd.O)--O--, --NH--(C.dbd.O)--, or --NH--CH.sub.2 --(C.dbd.O)-- residue; Y is O, or S; R.sub.2 is H; Z is a SO, SO.sub.2, --(CH.sub.2).sub.p --, --(CH.sub.2).sub.p --O--, --O--(CH.sub.2).sub.p --, --(CH.sub.2).sub.p --(C.dbd.O)--, --(C.dbd.O)--(CH.sub.2).sub.p --, --(CH.sub.2).sub.p --(C.dbd.O)--NH--, --NH--(C.dbd.O)--(CH.sub.2).sub.p --, --(CH.sub.2).sub.p --CHOH--, --CHOH--(CH.sub.2).sub.p --, --(CH.sub.2).sub.p --CH.dbd.CH--, or --CH.dbd.CH--(CH.sub.2).sub.p -- residue, wherein p is between 1 and 6; A is a phenyl, naphthyl, anthranyl, fluorenyl, thiophenyl, pyridinyl, isoxazolyl, benzimidazolyl, quinoxazolinyl, morpholinyl, or pyrrolidinyl residue; and, R.sub.3, R.sub.4, and R.sub.5, the same or different, are defined in the specification; and pharmaceutically acceptable salts, stereoisomers, racemates, racemic modifications, and enantiomers thereof. The invention also relates to specific compounds, processes for preparing and for treating an allergic, asthmatic, inflamed condition of a host, or for modulating the immune system of a host.

REFERENCES:
patent: 4537966 (1985-08-01), Murray
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File HCAPLUS on STN.RTM., Chemical Abstracts Service, (Columbus. Ohio), Accession No. 1996:489898; Meanwell, N.A. et al. Bioorg. Med. Chem. Lett., 6(14), 1641-1646 (1996), abstract. 1996.
File HCAPLUS on STN.RTM., Chemical Abstracts Service, (Columbus. Ohio), Accession No. 1973:43355; Corsi, G. Boll. Chim. Farm., 111(9), 566-72 (1972), abstract. 1973.
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