Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-04-15
2010-12-07
Stockton, Laura L. (Department: 1626)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C548S143000, C514S364000
Reexamination Certificate
active
07847100
ABSTRACT:
The present invention is directed to 1,3,5-phenyl substituted derivative compounds which are inhibitors of the beta-secretase enzyme and that are useful in the treatment of diseases in which the beta-secretase enzyme is involved, such as Alzheimer's disease. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the treatment of such diseases in which the beta-secretase enzyme is involved.
REFERENCES:
patent: 7109217 (2006-09-01), Coburn et al.
patent: 2006/0058278 (2006-03-01), Coburn et al.
patent: 2006/0149092 (2006-07-01), Nantermet et al.
patent: 2006/0161020 (2006-07-01), Coburn et al.
patent: WO 03/057721 (2003-07-01), None
patent: WO 03/072535 (2003-09-01), None
patent: WO 03/106405 (2003-12-01), None
patent: WO 2004/050619 (2004-06-01), None
patent: WO 2005/005374 (2005-01-01), None
patent: WO 2005/018545 (2005-03-01), None
patent: WO 2005/032471 (2005-04-01), None
patent: WO 2005/051914 (2005-06-01), None
patent: WO 2005/065195 (2005-07-01), None
patent: WO 2005/097767 (2005-10-01), None
patent: WO 2005/103043 (2005-11-01), None
J. Lloyd et al., “Design and Synthesis of 4-Substituted Benzamides as Potent, Selective, and Orally Bioavailable . . . ,” J. med. Chem., vol. 44, pp. 3764-3767 (2001).
C. Coburn et al., “Identification of a Small Molecule Nonpeptide Active Site Beta-Secretase Inhibitors . . . ,”, J. Med. Chem., vol. 47, pp. 6117-6119 (2004).
S. Stachel et al., “Structure-Based design of Potent and Selective Cell-Permeable Inhibitors of Human Beta-Secretase (BACE-1),” J. Med. Chem., vol. 47, pp. 6447-6450 (2004).
S. Stachel et al., “Conformationally biased P3 amide replacements of B-secretase inhibitors,” Biorganic & Medicinal Chemistry Letters, vol. 16, pp. 641-644 (2006).
Barrow James C.
Coburn Craig A.
McGaughey Georgia B.
Nantermet Philippe G.
Rajapakse Hemaka A.
MacMillan Keith D.
Merck, Sharp & Dohme, Inc.
Stockton Laura L.
Todaro John C.
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