1,3,4-thiadiazoles useful for the treatment of CMV infections

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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548139, C07D285135, A61K 31433

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active

061503851

ABSTRACT:
The present invention presents novel 1,3,4-thiadiazole derivatives of formula I ##STR1## which have useful antiviral activity against herpes virus, cytomegalovirus (CMV).

REFERENCES:
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Okawara, T, et al., "A New Route to 1,2,4-Triazoles and 1,3,4-Thiadiazoles from 1-Acylbithiourea," J. Heterocyclic Chem., 25:1071-1075 (1988).
F. Kurzer, "Heterocyclic Compounds from Urea Derivatives. Part XXI. Adducts from Thiocarbonohydrazides and Aroyl Isothiocyanates and Their Cyclisation," J. Chem. Soc. (C), 2932-2938 (1971).
F. Kurzer, "Heterocyclic Compounds from Urea Derivatives. Part XVIII. Adducts from Aminoguanidines and Aroyl Isothiocyanates and Their Cyclisation, " J. Chem. Soc. (C), 1805-1813 (1970).
F. Kurzer, "Heterocyclic Compounds from Urea Derivatives. Part XIX. Adducts from Diaminoguanidines and Aroyl Isothiocyanates and Their Cyclisation," J. Chem. Soc. (C), 13:1813-1823 (1970).
"Production of 2-acylamino-1,3,4-thiadiazole derivs.--by reacting n-acylimino:carbonic acid ester(s) with thiosemicarbazide or di:thiocarbazinic acid ester(s)" Derwent Abstracts 07484C/05.
"Anti-inflammatory composition containing 1,3,4-thiadiazole derivatives as active agent," Derwent Abstracts 46012X/24.
Patent Abstracts of Japan--vol. 199, No. 510; JP 07 188017 A, Jul. 25, 1995.
Patent Abstracts of Japan--vol. 199, No. 509, JP 07 149748 A, Jun. 13, 1995 .

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