1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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514326, 514364, 546209, 548136, 548143, 548144, A01K 3141, C07D28512, C07D27110

Patent

active

056681593

ABSTRACT:
##STR1## This invention relates to improved isoxazoline compounds including, but not limited to 1,3,4-thiadiazoles and 1,3,4-oxadiazoles of the formula which are useful as antagonists of the platelet glycoprotein IIb/IIIa fibrinogen receptor complex, to pharmaceutical compositions containing such compounds, and to methods of using these compounds, alone or in combination with other therapeutic agents, for the inhibition of platelet aggregation, as thrombolytics, and/or for the treatment of thromboembolic disorders.

REFERENCES:
patent: 5482966 (1996-01-01), Bird

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