1,3,4-oxadiazol-2-ones as PPAR delta modulators and their...

Details 1,3,4-oxadiazol-2-ones as PPAR delta modulators and their... 1,3,4-oxadiazol-2-ones as PPAR delta modulators and their...

2006-09-26

2009-08-18

Shameem, Golam M (Department: 1626)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

C548S125000, C548S143000, C548S144000, C514S361000

Reexamination Certificate

active

07576109

ABSTRACT:
The present invention is directed to 1,3,4-oxadiazolones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein.The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization.

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Kulkarni, S.S., et. al., Three-Dimensional Quantilative Structure Activity Relationships (3-D-QSAR) of Antihyperglycemic Agents, Bioorganic & Medicinal Chemistry vol. 7, (1999) pp. 1475-1485.

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