Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-01-18
2011-01-18
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S365000, C514S336000, C514S385000, C546S268100, C546S268400, C546S269400, C548S144000, C548S204000, C548S311100, C548S335100, C548S235000
Reexamination Certificate
active
07872032
ABSTRACT:
The present invention is directed to 1,3,4-oxadiazalones, compounds of formula I and their pharmaceutically acceptable salts stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein.The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization.
REFERENCES:
patent: 4895953 (1990-01-01), Musser et al.
patent: 5103014 (1992-04-01), Musser et al.
patent: 7638539 (2009-12-01), McGarry et al.
patent: WO 00/78313 (2000-12-01), None
patent: WO 01/00603 (2001-01-01), None
patent: WO 01/17994 (2001-03-01), None
Vippagunta et al., Advanced Drug Delivery Reviews, vol. 48, p. 3-26 ( on p. 3), 2001 (disclosed in the instant IDS).
Henke, B.R., et. al., N-(2-Benzoylphenyl)-L-Tyrosine PPARy Agonists. 1. Discovery of a Novel Series of Potent Antihyperglycemic and Antihyperlipidemic Agents, J. Med. Chem. (1998) vol. 41, pp. 5020-5036.
Kulkarni, S., et. al., Three Dimensional Quantitative Structure Activity Relationships (3-D-QSAR) of Antihyperglycemic Agents, Bioorganic & Medicinal Chemistry vol. 7, (1999) pp. 1475-1485.
Vippagunta, et. al., Crystalline Solids, Advanced Drug Delivery Reviews 48 (2001) pp. 3-26.
Peroxisome Proliferator-Activated Receptor Delta, Wikipedia.
Chandross Karen
Goerlitzer Jochen
Keil Stefanie
McGarry Daniel G.
Merrill Jean
Aventis Parmaceuticals Inc.
Chu Yong
Lin Jiang
Sanofi-Aventis Deutschland GmbH
LandOfFree
1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1, 3, 4-oxadiazol-2-ones as PPAR delta modulators and their... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2656561