1, 3, 4-oxadiazol-2-ones as peroxisome-proliferator...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S365000, C548S144000, C548S203000

Reexamination Certificate

active

07638539

ABSTRACT:
The present invention is directed to 1,3,4-oxadiazalones, i.e., the compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein.The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization such as multiple scleroses.

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patent: 5103014 (1992-04-01), Musser et al.
patent: WO 00/78313 (2000-12-01), None
patent: WO 01/00603 (2001-01-01), None
patent: WO 01/17994 (2001-03-01), None
Peroxisome proliferator-activated receptor delta, Wikipedia.
Vippagunta et al., Advanced Drug Delivery Reviews, p. 1.
Henke, B.R., et. al., N-(2-Benzoylphenyl)-L-Tyrosine PPARy Agonists. 1. Discovery of a Novel Series of Potent Anthyperglycemic and Antihyperlipidemic Agents, J. Med. Chem (1998) vol. 41, pp. 5020-5036.
Kulkarni, S., et. al., Three Dimensional Quantitative Structure Activity Relationships (3-D-QSAR) of Antihyperglycemic Agents, Bioorganic & Medicinal Chemistry, vol. 7, (1999) pp. 1475-1485.

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