Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2006-09-27
2009-12-29
Chu, Yong (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S365000, C548S144000, C548S203000
Reexamination Certificate
active
07638539
ABSTRACT:
The present invention is directed to 1,3,4-oxadiazalones, i.e., the compounds of formula I and their pharmaceutically acceptable salts, stereoisomers, tautomers, or solvates thereof. Novel compounds include those of formula I, in which radicals are as defined herein.The compounds of this invention are modulators of PPARdelta and therefore useful as pharmaceutical agents, especially for the treatment of demyelinating diseases and disorders of fatty acid metabolism and glucose utilization such as multiple scleroses.
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Peroxisome proliferator-activated receptor delta, Wikipedia.
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Henke, B.R., et. al., N-(2-Benzoylphenyl)-L-Tyrosine PPARy Agonists. 1. Discovery of a Novel Series of Potent Anthyperglycemic and Antihyperlipidemic Agents, J. Med. Chem (1998) vol. 41, pp. 5020-5036.
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Chandross Karen
Goerlitzer Jochen
Keil Stefanie
McGarry Daniel G.
Merrill Jean
Aventis Pharmaceuticals Inc.
Bell Craig
Chu Yong
Lin Jiang
Sanofi-Aventis Deutschland GmbH
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