1,3,4-benzotraizepin-5(4H)-one derivatives and process for the p

Details 1,3,4-benzotraizepin-5(4H)-one derivatives and process for the p 1,3,4-benzotraizepin-5(4H)-one derivatives and process for the p

1993-09-03

1995-08-15

Berch, Mark L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heterocyclic carbon compounds containing a hetero ring...

540501, C07D25504, C07D40306, C07D40112

Patent

active

054419484

ABSTRACT:
The invention relates to racemic or optically active 1,3,4-benzotriazepin-5(4H)-one derivatives, a process for the preparation thereof, pharmaceutical compositions comprising the same, to the use of the said compounds for the treatment of diseases and for the preparation of pharmaceutical compositions containing the said compounds as active agent.
The new compounds according to the invention correspond to the general formula (I), ##STR1## wherein R.sup.1 represents hydrogen or straight or branched chain C.sub.1-4 alkyl optionally carrying a pyridyl or a phenyl substituent;

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Omar, J. Het Chem 16, 1435 (1979).
Sunder, J. Het Chem 18, 1601-1604 (1981).
Tihanyi, Heterocycles 20, 571-574 (1983).
Barton, "Comprehensive Organic Chemistry" (Permagon Press) vol. 4, pp. 1024-1027 (1974).
Peet, J. Het Chem 21, 1807 (1984).
Davidson, Monat. Chem. 115, 565-571 (1984).
Davidson, Chem Abs 98, 179428u (1983).
Sakai, J. Pharm. Method. 5, 325-326 (1981).
Morgenstern, Pharmazie 47, 655 (1992).
Peet II, J Het. Chem. 21, 1817 (1984).

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