1-(3,3,3-Triarylalkyl)-4-phenyl-piperidinealkanols

Details 1-(3,3,3-Triarylalkyl)-4-phenyl-piperidinealkanols 1-(3,3,3-Triarylalkyl)-4-phenyl-piperidinealkanols

1976-10-18

1978-02-07

Trousof, Natalie

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26029381, 26029383, 26029384, 424263, 424267, 26029377, C07D40106, C07D21122

Patent

active

040726860

ABSTRACT:
The present invention encompasses compounds of the formula ##STR1## and pharmaceutically acceptable acid addition salts thereof wherein the Alk is straight or branched chain alkylene containing 2-4 carbon atoms; M is alkylene having 1-4 carbon atoms; Ar and Ar' are phenyl, alkyl substituted phenyl wherein the alkyl contains from 1-4 carbon atoms or halo substituted phenyl; Ar" is phenyl, alkyl substituted phenyl wherein the alkyl contains 1-4 carbon atoms, halo substituted phenyl or pyridyl; X is hydrogen, halogen, trifluoromethyl or alkyl having from 1-4 carbon atoms; R is hydrogen alkyl having from 1-7 carbon atoms or an alkanoyl having from 2-5 carbon atoms. These compounds are potent antidiarrheal agents characterized by little, if any, central nervous system activity.

REFERENCES:
patai et al., "J. Chem. Soc." pp. 716-723 (1962).
Martensson et al., "Acta Chim. Scand." vol. 19, No. 3, pp.711-722 (1965).
Bochow, "Chem. Ber." vol. 108 pp. 3475-3482 (1975).

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