1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflamm

Details 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflamm 1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides used as anti-inflamm

1975-03-27

1976-12-21

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

4242485, 424250, 42424854, A61K 3147

Patent

active

039989542

ABSTRACT:
1,3(2H,4H)-Dioxoisoquinoline-4-carboxamides, nuclear unsubstituted and substituted, are prepared by reacting the appropriate homophthalimide with potassium cyanate. Secondary carboxamides are prepared by reacting homophthalimide with appropriate isocyanates, and tertiary carboxamides are prepared by aminolysis of 4-carbalkoxy compounds, which are in turn prepared by alcoholysis of the corresponding 4-carboxanilides. Corresponding 5,6,7,8-tetrahydro compounds are similarly prepared. The various 2-substituted homophthalimides are prepared by reacting homophthalic acid with appropriate amine. The 4-carboxamides are anti-inflammatory agents.

REFERENCES:
patent: 3726875 (1973-04-01), Kadin
patent: 3886163 (1975-05-01), Kadin

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