Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Parasitic organism or component thereof or substance...
Patent
1982-09-29
1983-12-13
Bond, Robert T.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Parasitic organism or component thereof or substance...
424274, 546 17, 548408, A61K 31445, A61K 3142, C07D41314
Patent
active
044204850
ABSTRACT:
This invention relates to 1'-[3-(1,2-benzisoxazol-3-yl)propyl]spiro[benzofuran-2(3H),3' or 4'-piperidines or 3'-pyrrolidines] of the formula: ##STR1## where X and Y are the same or different and are hydrogen, halogen, lower alkoxy, lower alkyl, nitro, hydroxyl and CF.sub.3 ; and n is an integer of 1 or 2; m is an integer of 2 or 3; and the sum of m and n is 3 or 4; and the pharmaceutically acceptable acid addition salts thereof. These compounds are useful as antihypertensive agents.
REFERENCES:
patent: 3629239 (1971-12-01), Kitahonoki et al.
patent: 3732306 (1973-05-01), Gutman et al.
patent: 3951999 (1976-04-01), Saunders et al.
patent: 3960951 (1976-06-01), Gutman
patent: 4007227 (1977-02-01), Baker et al.
patent: 4128580 (1978-12-01), Matsumoto et al.
patent: 4166119 (1979-08-01), Effland et al.
patent: 4166120 (1979-08-01), Effland et al.
patent: 4192896 (1979-10-01), Uno et al.
patent: 4235914 (1980-11-01), Sasajima et al.
Uno et al., "Chem Pharm Bull" (Japan) vol. 24, No. 4, pp. 632-643.
Noller "Textbook of Organic Chemistry" 3rd Edition (1966) (Saunders) p. 169.
Katritzky "Advances in Heterocyclic Chemistry" vol. 8, pp. 283-286 (1967).
Chemical Abstracts, vol. 87, (1977) Item 39459C, abstracting Japan Kokai 76, 136,666, Nov. 26, 1979.
Janssen "Internationa J. Neuropharmacology" (1962) vol. 1, pp. 145-148.
U.S. Patent Application Ser. No. 06/257,698, filed Apr. 27, 1981.
U.S. Patent Application Ser. No. 06/366,247, filed Apr. 9, 1982.
Davis Larry
Pierrat Frank A.
Bond Robert T.
Hoechst-Roussel Pharmaceuticals Inc.
Rosenstock Jerome
LandOfFree
1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' o does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' o, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1'-[3-(1,2-Benzisoxazol-3-yl) proply]spiro[benzofuran-2(3H),3' o will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-804138