(1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

546 99, 548427, 548450, C07D20960, A61K 3140

Patent

active

054912369

ABSTRACT:
This invention is therapeutically useful tetralins and pharmaceutically acceptable acid addition salts thereof of the formula ##STR1## wherein R, R.sub.1 and A are as defined in claim 1. These compounds are useful to treat central nervous system disorders.

REFERENCES:
patent: 4234731 (1980-11-01), Kavadias
patent: 4618683 (1986-10-01), De Bernadis et al.
patent: 5030636 (1991-07-01), Imhof et al.
patent: 5180733 (1993-01-01), Basha et al.
patent: 5244888 (1993-09-01), De Bernards et al.
patent: 5248677 (1993-09-01), Basha et al.
patent: 5318966 (1994-06-01), Brudener et al.
patent: 5318967 (1994-06-01), Brudener et al.
A. Kumar, et al., "Studies on analgesic-narcotic antagonists: synthesis of N-substituted 1,2,3,4,4a,5,6,10b-octahydrobenzo[f]-quinolines", p. 456, abstract 5285g, Chemical Abstracts, vol. 86, 1977 & Indian J. Chem, Sect. B 1976 14B(7), 556-7.
H. Wikstrom et al., "N-substituted 1,2,3,4,4a,5,6,10b-octhydrobenzo[f]quinolines and 3-phenylpiperindes: effects on central dopamine and .beta.receptors", pp. 2169-2174 (see compounds 11-33) Journal of Medicnal Chemistry, vol. 30, No. 12, 1987, American Chemical Society.
J. G. Cannon et al., "Rigid congeners of dopamine based on octahydrobenzo[f]quinoline: peripheral and central effects" pp. 341-347 (see compounds 1-7, 13-16) Journal of Medicinal Chemistry, vol. 22, No. 4, 1979, American Chemical Society.
J. G. Cannon et al., "Congeners of the .beta.conformer of dopamine derived from cis-- and trans-octahydrobenzo[f]quinoline and trans-octahrydrobenzo[f]quinoline and trans-octahydrobenzo[g]quinoline", pp. 1-5 (see Table I), Journal of Medicinal Chemistry, vol. 213, No. 1, Jan. 1980, American Chemical Society.
H. Wikstrom et al., "Monophenolic octahydrobenzo[f]quinolines: central dopamine-- and serotonin-receptor stimulating activity" pp. 925-931 (see compounds 6-19) Journal of Medicinal Chemistry, vol. 25, No. 8, 1982 American Chemical Society.
J. G. Cannon et al., "Conformationally restriced congeners of dopamine derived from octahydrobenzo[g]quinoline and octahydrobenzo[f]quinoline " pp. 190-195 (see compounds 16, 42-50) Journal of Medicinal Chemistry, vol. 27, No. 2, 1984, American Chemical Society.
J. G. Cannon et al., "p-dimethoxy-substituted trans-octahydrobenzo[f]and --[g ]quinolines: synthesis and assessment of dopaminergic agonist effects" pp. 2529-2534 (see compounds 8,9,13)Journal of Medicinal Chemistry, vol. 29, No. 12, 1986, American Chemical Society.
J. G. Cannon et al., "Assessment of a potential dopaminergic prodrug moiety in several ring systems", pp. 2016-2020(see compounds 4a-4d) Journal of Medicinal Chemistry, vol. 29, No. 10, 1986, American Chemical Society.
H. Wikstrom et al., "Resolved cis-10-hydroxy-4-n-propyl-1,2,3,4,4a,5,6,10b-octahydrobenzo f quinoline: central serotonin stimulating properties"pp. 1567-1573 (see p. 1567) Journal of Medicinal Chemistry, vol. 30, No. 9, Sep. 1987, American Chemical Society.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

(1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with (1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and (1,2N) and (3,2N)-carbocyclic-2-amino tetralin derivatives will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-241602

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.