1,25-Dihydroxy-24-oxo-vitamin D.sub.3 and 1,23,25-trihydroxy-24-

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – 9,10-seco- cyclopentanohydrophenanthrene ring system doai

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2603972, A61K 3159

Patent

active

044951817

ABSTRACT:
Novel biologically active metabolites of vitamin D.sub.3, 1,23,25-trihydroxy-24-oxo-vitamin D.sub.3 (1,23,25(OH).sub.3 -24-oxo-D.sub.3); and 1,25,-Dihydroxy-24-oxo-vitamin D.sub.3 (1,25(OH).sub.2 -24-oxo-D.sub.3). Also the method of preparing these novel metabolites of vitamin D.sub.3. The use of these compounds in humans for the treatment of disease states involving calcium homeostatic disorders by the administration of an effective amount of said compounds.

REFERENCES:
Yamada et al., "Jour. Biological Chem.", vol. 258, No. 1, Jan. 10, 1983, pp. 457-463.

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