1,24-dihydroxy-.DELTA..sup.22 -vitamin D.sub.3 and process for p

Details 1,24-dihydroxy-.DELTA..sup.22 -vitamin D.sub.3 and process for p 1,24-dihydroxy-.DELTA..sup.22 -vitamin D.sub.3 and process for p

1984-05-31

1986-05-13

Roberts, Elbert L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

26023955R, 2602395, 2603974, C07J 700

Patent

active

045885281

ABSTRACT:
The invention provides new derivatives of vitamin D.sub.3 and specifically (22E,24R)-1,24-dihydroxy-.DELTA..sup.22 -vitamin D.sub.3 and (22E,24S)-1,24-dihdroxy-.DELTA..sup.22 -vitamin D.sub.3.
The compounds exhibit vitamin D-like activity in their ability to stimulate intestinal calcium transport, increase serum inorganic phosphorous and mineralize bone indication ready application of the compounds in the treatment of various metabolic bone diseases. The characteristic of the compounds to not mobilize bone indicates that the compositions would find ready application in combination with vitamin D and various of its derivatives to achieve controlled bone mineralization.

REFERENCES:
patent: 4225596 (1980-09-01), DeLuca

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