1,2-Pentamethylene-1,4-dihydropyridine derivatives

Details 1,2-Pentamethylene-1,4-dihydropyridine derivatives 1,2-Pentamethylene-1,4-dihydropyridine derivatives

1974-05-10

1976-04-20

Rotman, Alan L.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

2602948C, 2602955B, 424266, C07D21355

Patent

active

039519880

ABSTRACT:
1,4-Dihydropyridines bearing carbonyl functions in the 3- and 5-positions, being optionally substituted by lower alkyl in the 6-position, being substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group, and being fused through the 1- and 2-positions to a five, six or seven membered cycloalkyl ring, one methylene group of which can be replaced by sulfur, oxygen imino or alkylimino, are antihypertensive agents and coronary vessel dilators. The compounds, of which 6-methyl-4-(3-nitrophenyl)-1,2-pentamethylene-1,4-dihydropyridine-3,5-dica rboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and a cyclic enamino carbonyl derivative.

REFERENCES:
patent: 3784600 (1974-01-01), Strandtmann et al.

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