1,2-Modified fortimicins A and B, intermediates therefor and met

Details 1,2-Modified fortimicins A and B, intermediates therefor and met 1,2-Modified fortimicins A and B, intermediates therefor and met

1980-10-28

1982-07-20

Brown, Johnnie R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

424180, C07H 1522

Patent

active

043407277

ABSTRACT:
A 1,2-modified fortimicin A or B represented by the formulae I, II and III: ##STR1## wherein R is hydrogen or loweralkyl; and R.sub.1 is selected from the group consisting of hydrogen, loweralkyl, aminoloweralkyl, diaminoloweralkyl, N-lower-alkylaminoloweralkyl, N,N-diloweralkylaminoloweralkyl, hydroxyloweralkyl, amino hydroxyloweralkyl, N-loweralkylaminohydroxyloweralkyl, N-N-diloweralkylaminohydroxyloweralkyl, acyl, aminoacyl, hydroxy-substituted aminoacyl, diaminoacyl, hydroxyacyl, hydroxy-substituted diaminoacyl, N-loweralkylaminoacyl, N, N-diloweralkylaminoacyl, hydroxysubstituted-N-loweralkylaminoacyl and hydroxy-substituted-N, N-diloweralkylaminoacyl, and the pharmaceutically acceptable salts thereof. The compounds are broad spectrum antibiotics.

REFERENCES:
patent: 4091032 (1978-05-01), Tadanier et al.
patent: 4218442 (1980-08-01), McAlpine et al.
patent: 4220755 (1980-09-01), Sato et al.

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