1,2-hydroxy phosphonates and derivatives thereof

Details 1,2-hydroxy phosphonates and derivatives thereof 1,2-hydroxy phosphonates and derivatives thereof

1990-04-12

1993-06-08

Lee, Lester L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

530331, 514 18, 544118, 544119, 544122, 544133, 544137, 544157, A61K 3702, C07K 506

Patent

active

052179583

ABSTRACT:
Compounds of the formula ##STR1## are disclosed. These compounds are inhibitors of renin and therefore useful as cardiovascular agents.

REFERENCES:
Chemical Abstracts, vol. 98, p. 646 (72259n) (1983).
Organometallics, vol. 90, p. 527 (72285c) (1979).
Powers et al., "Inhibition of Human Leukoctye Elastase, Porcine Pancreatic Elastase and Cathepsin G by Peptide Ketones", Proceedings from 9th American Peptide Symposium, Jun. 23-28, 1985, Univ. of Toronto, Canada.

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