1,2-ethanediol derivative and salt thereof and cerebral function

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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548179, 548205, 5483044, 5483401, 548486, 548490, 548503, 549 75, 549362, 549443, 549467, 549491, 514249, 514253, 514311, 514312, 514351, 514352, 514357, 514367, 514394, 514415, 514418, 514438, 514452, 514463, 514469, 514471, 544124, 544353, 544376, 546158, 546166, 546176, 546300, 546312, 546334, A61K 3134, C07D30781

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active

056589042

ABSTRACT:
This invention relates to a 1,2-ethanediol derivative and a salt thereof, a process for producing the same, and a cerebral function-improving agent comprising the same. The cerebral function-improving agent of this invention is useful for treating cerebrovascular dementia, senile dementia, Alzheimer's dementia, sequelae of ischemic encephalopathy and cerebral apoplexy.

REFERENCES:
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The Journal of Organic Chemistry, vol. 51, No. 15, Jul. 15, 1986, pp. 2952-2955, Robert C. Moschel, et al., "Hydrolysis and Rearrangementof 06-Substituted Guanosine Products Resulting From Reaction of Guannosine with Styrene Oxide".
Archiv der Pharmazie, vol. 296, No. 1, 1963, pp. 38-47, K. Winterfeld, et al., "Zur Kenntnis Phenyl-Substituierter Oxa-Chinolizidine".
The Journal of Organic Chemistry, vol. 50, No. 20, Oct. 4, 1985, pp. 3942-3943, William R. Baker, "Metalation of 4,5-Diphenyl-2-[2-(Trimethylstannyl)ethyl]oxazole with Titanium Tetra-Chloride. A New Carbon-Carbon Bond Forming Methodology Based on Organotitanium Reagents".
Rencl. Accad. Mat. 40 (Quaranta) [4], 1968, pp. 269-280, Leandro Baiocchi, et al., "Su Alcune Trasposizioni Nella Serie Dell'Indazolo".

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