1,2-Dithiole pyrimidines

Details 1,2-Dithiole pyrimidines 1,2-Dithiole pyrimidines

1977-11-28

1979-03-13

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

26032682, 544122, 544333, 544336, A61K 31505

Patent

active

041443390

ABSTRACT:
1,2-Dithiole derivatives of the formula: ##STR1## wherein Het represents an aromatic heterocyclic radical with six atoms in the ring two of which are nitrogen atoms, the heterocyclic radical optionally carrying a single substituent selected from halogen, alkyl, alkoxy, mercapto, alkylthio, dialkylamino, pyrrolidin-1-yl, piperidino, morpholino and 4-alkylpiperazin-1-yl, and R represents halogen, alkyl (optionally substituted by alkoxycarbonyl), carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or a group R.sub.1 --CH(OH)-- in which R.sub.1 represents hydrogen or alkyl, the said alkyl, alkoxy and alkylthio radicals or alkyl or alkoxy moieties containing 1 to 4 carbon atoms except in the case of R.sub.1 which contains 1 to 3 carbon atoms when an alkyl radical, are new compounds useful in the treatment of bilharziasis.

REFERENCES:
patent: 3979388 (1976-09-01), Krenzer
"The Chemistry of Heterocyclic Compounds", vol. 21, First Part, pp. 382-384 (1966).
Bottcher et al., Chem. Ber. 84, pp. 458-463 (1951).
Legrand et al., Bull. Soc. Chim, France, pp. 79-83 (1955).

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