1,2-Dithiole derivatives

Details 1,2-Dithiole derivatives 1,2-Dithiole derivatives

1977-02-09

1978-08-29

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544120, 544238, 544379, 544405, 544333, 544335, 544224, 544406, 544386, 544389, 544298, 544295, 544357, A61K 31495, A61K 3150, A61K 31505, C07D24102

Patent

active

041104501

ABSTRACT:
1,2-Dithiole derivatives of the formula: ##STR1## WHEREIN Het represents an aromatic heterocyclic radical with six atoms in the ring two of which are nitrogen atoms, the heterocyclic radical optionally carrying a single substituent selected from halogen, alkyl, alkoxy, mercapto, alkylthio, dialkylamino, pyrrolidin-1-yl, piperidino, morpholino and 4-alkylpiperazin-1-yl and R represents halogen, alkyl (optionally substituted by alkoxycarbonyl), carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or a group R.sub.1 --C(OH)-- in which R.sub.1 represents hydrogen or alkyl, the said alkyl, alkoxy and alkylthio radicals or alkyl or alkoxy moieties containing 1 to 4 carbon atoms except in the case of R.sub.1 which contains 1 to 3 carbon atoms when an alkyl radical, are new compounds useful in the treatment of bilharziasis.

REFERENCES:
The Chemistry of Heterocyclic Compounds, vol. 21, First Part, pp. 382-384, (1966).
Bottcher et al., Chem. Ber. 84, pp. 458-463 (1951).
Legrand et al., Bull. Soc. Chim. France, pp. 79-83 (1955).
Patrick Joseph Brown, Chemical Abstracts, vol. 73, 3942b, (1970).

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