1,2-Dithiole derivatives

Details 1,2-Dithiole derivatives 1,2-Dithiole derivatives

1977-11-28

1979-02-06

Tovar, Jose

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

544238, C07D23708, C07D23718, C07D23720

Patent

active

041384873

ABSTRACT:
1,2-Dithiole derivatives of the formula: ##STR1## wherein Het represents an aromatic heterocyclic radical with six atoms in the ring two of which are nitrogen atoms, the heterocyclic radical optionally carrying a single substituent selected from halogen, alkyl, alkoxy, mercapto, alkylthio, dialkylamino, pyrrolidin-1-yl, piperidino, morpholino and 4-alkylpiperazin-1-yl, and R represents halogen, alkyl (optionally substituted by alkoxycarbonyl), carboxy, alkoxycarbonyl, carbamoyl, N-alkylcarbamoyl or a group R.sub.1 --CH(OH)-- in which R.sub.1 represents hydrogen or alkyl, the said alkyl, alkoxy and alkylthio radicals or alkyl or alkoxy moieties containing 1 to 4 carbon atoms except in the case of R.sub.1 which contains 1 to 3 carbon atoms when an alkyl radical, are new compounds useful in the treatment of bilharziasis.

REFERENCES:
Bottcher et al., Chem. Ber. 84, pp. 458-463 (1951).
Legrand et al., Bull. Soc. Chim. (France) pp. 79-83, (1955).
The Chemistry of Heterocyclic Compounds, vol. 21, 1st part, "Multi-Sulfur and Sulfur and Oxygen Five and Six Membered Heterocycles", pp. 382-384, Interscience Publishers, (1966).

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