Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1995-06-07
1997-11-25
Barts, Samuel
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514441, 514262, 514274, A61K 31495
Patent
active
056913389
ABSTRACT:
This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a 1,2-dithiole-3-thione. A composition for inhibiting reverse transcriptase-dependent viral replication of cells comprising an effective amount of a 1,2-dithiole-3-thione and a physiologically acceptable carrier is also provided.
REFERENCES:
Roebuck, B.D., et al., Cancer Research 51:5501-5506 (1991). (Exhibit B).
Kensler, T.W., et al., Cancer Research 47:4271-4277 (1987). (Exhibit C).
Kong, X., et al., Antimicrobial Agents and ChemoTherapy 35(10):2003-2011. (Exhibit D); (1991).
DeClercq, E., AIDS Research And Human Retroviruses, 8(2):119-134. (Exhibit E). 1992.
Benson, A.B., Journal of Cellular Biochemistry, Supplement 17F: 278-291 (Aug. 1993). (Exhibit B).
CA117:165717; Chemical Abstract; STN OnLine 1991.
CA115:270158; Chemical Abstract; STN OnLine 1991.
Polsky Bruce
Prochaska Hans J.
Barts Samuel
Sloan-Kettering Institute for Cancer Research
White John P.
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