1,2-dithiole-3 thiones for the treatment of reverse transcriptas

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

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514441, 514262, 514274, A61K 31495

Patent

active

056913389

ABSTRACT:
This invention provides a method of inhibiting the replication of a reverse transcriptase-dependent virus in cells which comprises contacting infected cells with an effective amount of a 1,2-dithiole-3-thione. A composition for inhibiting reverse transcriptase-dependent viral replication of cells comprising an effective amount of a 1,2-dithiole-3-thione and a physiologically acceptable carrier is also provided.

REFERENCES:
Roebuck, B.D., et al., Cancer Research 51:5501-5506 (1991). (Exhibit B).
Kensler, T.W., et al., Cancer Research 47:4271-4277 (1987). (Exhibit C).
Kong, X., et al., Antimicrobial Agents and ChemoTherapy 35(10):2003-2011. (Exhibit D); (1991).
DeClercq, E., AIDS Research And Human Retroviruses, 8(2):119-134. (Exhibit E). 1992.
Benson, A.B., Journal of Cellular Biochemistry, Supplement 17F: 278-291 (Aug. 1993). (Exhibit B).
CA117:165717; Chemical Abstract; STN OnLine 1991.
CA115:270158; Chemical Abstract; STN OnLine 1991.

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