1,2-dithiin antiinfective agents

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

549 14, 549 20, 568 47, A61K 31385, C07C32106, C07D33908

Patent

active

056681682

ABSTRACT:
This invention pertains to a novel group of 1,2-dithiin compounds useful as antiinfective agents, and a novel synthetic process to produce the same. The compounds are particularly effective in treating fungal infections, especially those caused by Candida albicans, Cryptococcus neoformans or Aspergillus fumigatus.

REFERENCES:
patent: 4659733 (1987-04-01), DuPriest et al.
patent: 5202348 (1993-04-01), Towers et al.
Koreeda and Yang, 1994, "The chemistry of 1,2-dithiins: Synthesis of 1,2-dithiins and 3,6-disubstituted 1,2-dithiins", Synlett 3:201-203.
Cimiraglia et al., 1991, "An ab initio study of the structure and electronic spectrum of 1,2-dithiete and 1,2-dithiin", J Mol Struct 230:287-293.
Aihara, 1990, "Chemical evolution, biosynthesis, and aromaticity", Bull Chem Soc Jpn 63:2899-2903.
Balza and Towers, 1990,"Dithiacyclohexadiene chlorohydrins and related sulphur containing polyynes from Ambrosia chamissonis", Phytochemistry 29(9):2901-2904.
Constabel and Towers, 1989, "The complex nature of the mechanism of toxicity of antibiotic dithiacyclohexadiene polyines (thiarubrines) from the asteraceae", Planta Medica 55:35-37.
Balza et al., 1989, "Dithiacyclohexadienes and thiophenes from Ambrosia chamissonis", Phytochemistry 28(12):3523-3524.
Schroth et al., 1967, "1,2-Dithiins, a new type of heterocycle", Angewandte Chemie Intl Ed in Engl 6(8):698-699.
Schroth et al., 1966, "Stereoisomeric 1,4-dimercaptobutadienes", Chemical Abstracts issued Jan. 31, 1966, see abstract number 64:3339a.
Freeman et al., 1993, "Naturally occurring 1,2-dithiins", in Reviews on Heteroatom Chemistry, S. Oae (ed.), 9:1-19.
Freeman and Kim, 1989, "The Chemistry of 1,2-Dithiins," Sulfur Reports 9(3):207-256.
Facian et al., "A Thiactical Study of the Disulfide/Dithione Valence Isonerism", Collect. Czech. Chem. Commun., 53:2076-115 (1988).
Dzhemilev et al., 1986, "A new catalytic reaction of elemental sulfur with acetylenes by the action of cobalt complexes", Izv. Akad. Nauk SSSR, Ser. Khim. 5:1211-1212.
Dzhemilev et al., 1987, "An original method for the preparation of sulfides and disulfides involving cobalt complexes", Izv. Akad. Nauk SSSR, Ser. Khim. 8:1918.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

1,2-dithiin antiinfective agents does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with 1,2-dithiin antiinfective agents, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and 1,2-dithiin antiinfective agents will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-218761

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.