1,2-disubstituted heterocyclic compounds

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C514S249000, C514S252040, C514S256000, C514S266210, C514S300000, C514S312000, C514S338000, C544S216000, C544S238000, C544S284000, C544S333000, C544S353000, C546S122000, C546S153000, C546S270100, C546S271700, C546S273400

Reexamination Certificate

active

08071595

ABSTRACT:
1,2-disubstituted heterocyclic compounds which are inhibitors of phosphodiesterase 10 are described. Also described are processes, pharmaceutical compositions, pharmaceutical preparations and pharmaceutical use of the compounds in the treatment of mammals, including human(s) for central nervous system (CNS) disorders and other disorders which may affect CNS function. Among the disorders which may be treated are neurological, neurodegenerative and psychiatric disorders including, but not limited to, those associated with cognitive deficits or schizophrenic symptoms.

REFERENCES:
patent: 1541149 (2005-06-01), None
patent: WO2006/072828 (2006-07-01), None
patent: WO2007/077490 (2007-07-01), None
patent: WO2007/129183 (2007-11-01), None
patent: WO 2008/033455 (2008-03-01), None
Patani et al., Bioisosterism: A Rational Approach in Drug Design, 1996, Chem. Rev., 96, 3147-3176.
Navidpour et al., Design and synthesis of new water-soluble tetrazolide derivatives of celecoxib and refecoxib as selective cyclooxygenase-2 (COX-2) inhibitors, 2006, Bioorganic & Medicinal Chemistry Letters, 16, 4483-4487.

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