1,2-disubstituted ethyl amides as inhibitors of ACAT

Details 1,2-disubstituted ethyl amides as inhibitors of ACAT 1,2-disubstituted ethyl amides as inhibitors of ACAT

1992-09-23

1994-06-14

Ivy, C. Warren

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

5142378, 514255, 514327, 514328, 514329, 514331, 514617, 514627, 544168, 544389, 544390, 544391, 546 16, 546 19, 546220, 546221, 546222, 546223, 546224, 546233, 546234, 564181, 564207, A61K 3144, C07D22120, C07D24104, C07C23301

Patent

active

053210310

ABSTRACT:
Amides of the formula ##STR1## wherein: R.sup.1 is A and R.sup.2 is B; R.sup.1 is B and R.sup.2 is A; or R.sup.1 and R.sup.2 are independently selected from the group B;

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patent: 4603145 (1986-07-01), DeVries et al.
patent: 4611063 (1986-09-01), Damon, II
patent: 4716175 (1987-12-01), Hoefle et al.
patent: 5149709 (1992-09-01), Clader et al.
Nishida et al "Purpactins, New Inhibitor of ACAT" Biological Abs. 91:129161 (1991).
DeVries et al "Potential Antiatherosclerotic Agents" J. Med. Chem. 32 2318-25 (1989).

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