1,2-disubstituted aromatic chelates

Details 1,2-disubstituted aromatic chelates 1,2-disubstituted aromatic chelates

1994-08-19

1997-01-21

Nazario-Gonzales, Porfirio

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Heavy metal containing doai

514494, 514499, 514501, 514502, 556 1, 556 45, 556 50, 556 57, 556 62, 556 63, 556113, 556117, 556135, 556150, A61K 3128, C07F 1500, C07F 300, C07F 1100

Patent

active

055960162

ABSTRACT:
Mineral absorption is promoted in warm-blooded animals by means of a class of 1,2-disubstituted aromatic mineral chelates wherein the 1 and 2 substituents each donates a pair of electrons to a metal ion for formation of a five-member chelate ring. 2-Alkoxyphenols are particularly preferred. The chelates contain from one to three alkoxyphenol ligands, with two ligands being preferred. A preferred alkoxyphenol is vanillin, and the minerals are selected from the group consisting of Mg, Ca, Cr, Mn, Fe, Co, Cu, Zn, Mo, and Se. Vanillin metal chelates have a slight to neutral taste, and are absorbed more readily than inorganic mineral salts.

REFERENCES:
Bullock et al., Inorganica Chimica Acta, vol. 19, No. 1, pp. 79-85 (1976).
Bullock et al., J. Chem. Soc. (A), pp. 2351-2355 (1971).
Bullock et al., J. Chem. Soc. (A), pp. 2472-2475 (1970).
Betran Martinez et al., Chemical Abstracts, vol. 75, No. 26, Chem. Abs. No. 157706f, p. 424 (1971).
Sellmann et al., J. Organomet. Chem., vol. 297, pp. 319-329 (1985).
James H. Weber, Syn. React. Inorg. Metal-Org. Chem., vol. 7, No. 3, pp. 243-252 (1977).
Anzai et al., Chemical Abstracts, vol. 88, No. 6, Abs. No. 41632t p. 248 (1978).
Anzai et al., Chemical Abstracts, vol. 88, No. 14, Abs. No. 94776z, p. 331 (1978).
Baslas, Chemical Abstracts, vol. 110, No. 2, Abs. No. 13371m, p. 328 (1989) .

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