1,2-diphenylpyrrole derivatives, their preparation and their the

Details 1,2-diphenylpyrrole derivatives, their preparation and their the 1,2-diphenylpyrrole derivatives, their preparation and their the

1997-03-26

1999-06-01

Stockton, Laura L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514422, 548517, 548526, 548562, 548563, A61K 3140, C07D207333, C07D207335, C07D207337

Patent

active

059088583

ABSTRACT:
Compounds of formula (I) and (II): ##STR1## substituted amino; R.sup.2 is optionally substituted phenyl; R.sup.3 is hydrogen, halogen or optionally substituted alkyl; R.sup.4 is hydrogen, optionally substituted alkyl, cycloalkyl, aryl, or aralkyl! have valuable analgesic, anti-inflammatory, anti-pyretic and anti-allergic activities and have the ability to inhibit the production of leukotrienes and to inhibit bone resorption. They are relatively free from the side effects which generally result from the administration of compounds having these kinds of activities.

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patent: 5418254 (1995-05-01), Huang et al.
patent: 5434178 (1995-07-01), Talley et al.
patent: 5486534 (1996-01-01), Lee et al.
Chemical Abstracts, vol. 105, No. 17, Oct. 27, 1986, Columbus, Ohio, Abstract No. 152868p, LI, et al: "Synthesis and properties of 1-aryl-3-benzoyl-2-,5-diphenylpyrroles" of Gaodeng Xuexiao Huaxue Xuebao (1985), 6(10), 917-18.
Chemical Abstracts, vol. 104, No. 15, Apr. 14, 1986, Columbus, Ohio, Abstract No. 129728p, LI, et al: "Synthesis and properties of polysubstituted pyrroles, (II)" of Gaodeng Xuexiao Huaxue Xuebao (1985), 6(6), 513-14.

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