Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1977-03-14
1979-02-13
Trousof, Natalie
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C07D23108
Patent
active
041397096
ABSTRACT:
The compound 1,2-Diphenyl-3,5-ditrifluoroacetyloxy-4-butyl-5-hydroxy-3-pyrazoline is disclosed as an intermediate useful in the preparation of selected pro-phenylbutazone derivatives.
Such selected pro-phenylbutazone derivatives are novel, transient, pro-drug forms of phenylbutazone and oxyphenbutazone having the following formulae wherein R, R.sub.2, R.sub.4, R.sub.5, X and Y are as defined herein: ##STR1## The above-identified compounds exhibit anti-inflammatory activity in warm-blooded animals. Upon administration to warm-blooded animals, these compounds pass through the gastrointenstinal tract and cleave in the bloodstream, thus releasing phenylbutazone or oxyphenbutazone in an anti-inflammatory effective amount at their therapeutic site or sites of activity.
REFERENCES:
patent: 3847936 (1974-11-01), Adolphi et al.
Sloan et al., J. Org. Chem., 1976, vol. 41, pp. 165-166.
Sala et al., Chimie Therapeutique, 1967, No. 4, 272-276.
Sloan et al., Chem. Absts., vol. 84, 1976, 43929m.
Chem. Absts., vol. 84, 1976, p. 44336, col. 2.
Bodor Nicolae S.
Sloan Kenneth B.
Harkaway Natalia
Interx Research Corporation
Trousof Natalie
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