1,2-dioxetane compounds with haloalkoxy groups, methods preparat

Details 1,2-dioxetane compounds with haloalkoxy groups, methods preparat 1,2-dioxetane compounds with haloalkoxy groups, methods preparat

1994-11-14

1998-06-30

Shah, Mukund J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549332, 252700, C07D32100, C09K 300, C07C 43176, C12Q 125

Patent

active

057736286

ABSTRACT:
A chemiluminescent assay method and compositions are described which use a haloalkoxy group-substituted dioxetane which is deprotected by a hydrolytic enzyme to undergo a chemiluminescent reaction. Chemiluminescent 1,2-dioxetane compounds substituted on the dioxetane ring with a haloalkoxy group which can be triggered by a reagent to generate light are disclosed. Haloalkoxy group-substituted dioxetanes are useful for the detection of triggering agents including enzymes. The enzyme may be present alone or linked to a member of a specific binding pair in an immunoassay, DNA probe assay or other assay where the enzyme is bound to a reporter molecule.

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