1,2-Dioxetane compounds as chemiluminescent labels for organic a

Details 1,2-Dioxetane compounds as chemiluminescent labels for organic a 1,2-Dioxetane compounds as chemiluminescent labels for organic a

1994-03-25

1998-06-23

Owens, Amelia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

548406, 549214, 549332, C07D40502, C07D30504

Patent

active

057707430

ABSTRACT:
Dioxetanes which couple with organic and biological molecules of the formula: ##STR1## wherein X is a leaving group which is removed by an activating agent other than an enzyme which is removed by an activating agent to produce light, wherein A is a coupling substituent, Ar is a substituent selected from the group consisting of phenyl and naphthyl to provide a label are described. R.sub.1 is an optional linker substituent and can have between 1 and 30 carbon atoms with some of the carbon atoms being oxygen, sulfur, nitrogen or phosphorus. Ar as phenyl is preferred. The dioxetane coupled molecules are useful in assays of all types where luminescence can be used as an indicator.

REFERENCES:
patent: 4555509 (1985-11-01), Evans et al.
patent: 4950588 (1990-08-01), Dattagupta

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