Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1985-03-28
1986-07-15
Hollrah, Glennon H.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
544350, 546308, A61K 31495, C07D47104, C07D21361
Patent
active
046007164
ABSTRACT:
1,2-Dihydropyrido[3,4-b]pyrazines are provided which possess anticancer activity. The compounds have the structure: ##STR1## wherein Y is CH.sub.2 or N(CH.sub.3); R.sub.1 is a lower alkyl group; e.g., an alkyl group containing up to six carbon atoms such as methyl, ethyl, propyl, butyl, etc.; R.sub.2 is a member selected from the group consisting of hydrogen, CH.sub.3 O or Cl; and R.sub.3 and R.sub.4 are either both hydrogen or one is hydrogen and the other is a lower alkyl group.
REFERENCES:
patent: 4450160 (1984-05-01), Temple, Jr. et al.
Wheeler, et al., "Chemical Abstracts", vol. 96, 1982, col. 96:79528s.
Hamel, et al., "Chemical Abstracts", vol. 96, 1982, col. 96:135450z.
Wheeler, et al., "Chemical Abstracts", vol. 96, 1982, col. 96:155154j.
Temple, et al., "Chemical Abstracts", vol. 97, 1982, col. 97:109969b.
Temple, et al., "Chemical Abstracts", vol. 100, 1984, col. 100:121106f.
Elliott Robert D.
Montgomery John A.
Temple Carroll G.
Wheeler Glynn P.
Hollrah Glennon H.
Southern Research Institute
Turnipseed James H.
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